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1.

Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul, Yoav D; Freinkman, Elizaveta; Comb, William C; Cantor, Jason R; Tam, Wai Leong; Thiru, Prathapan; Kim, Dohoon; Kanarek, Naama; Pacold, Michael E; Chen, Walter W; Bierie, Brian; Possemato, Richard; Reinhardt, Ferenc; Weinberg, Robert A; Yaffe, Michael B; Sabatini, David M.

Cell; 158(5): 1094-1109, 2014 Aug 28.

Artículo en Inglés | MEDLINE | ID: mdl-25171410

2.

The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.

Khatib, Anees; Solaimuthu, Balakrishnan; Ben Yosef, Michal; Abu Rmaileh, Areej; Tanna, Mayur; Oren, Gidi; Schlesinger Frisch, Michal; Axelrod, Jonathan H; Lichtenstein, Michal; Shaul, Yoav D.

Proc Natl Acad Sci U S A; 117(35): 21420-21431, 2020 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-32817494

3.

Overexpression of UBA5 in Cells Mimics the Phenotype of Cells Lacking UBA5.

Kumari, Sujata; Banerjee, Sayanika; Kumar, Manoj; Hayashi, Arata; Solaimuthu, Balakrishnan; Cohen-Kfir, Einav; Shaul, Yoav D; Rouvinski, Alexander; Wiener, Reuven.

Int J Mol Sci; 23(13)2022 Jul 04.

Artículo en Inglés | MEDLINE | ID: mdl-35806453

4.

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold, Michael E; Brimacombe, Kyle R; Chan, Sze Ham; Rohde, Jason M; Lewis, Caroline A; Swier, Lotteke J Y M; Possemato, Richard; Chen, Walter W; Sullivan, Lucas B; Fiske, Brian P; Cho, Steve; Freinkman, Elizaveta; Birsoy, Kivanç; Abu-Remaileh, Monther; Shaul, Yoav D; Liu, Chieh Min; Zhou, Minerva; Koh, Min Jung; Chung, Haeyoon; Davidson, Shawn M; Luengo, Alba; Wang, Amy Q; Xu, Xin; Yasgar, Adam; Liu, Li; Rai, Ganesha; Westover, Kenneth D; Vander Heiden, Matthew G; Shen, Min; Gray, Nathanael S; Boxer, Matthew B; Sabatini, David M.

Nat Chem Biol; 12(6): 452-8, 2016 06.

Artículo en Inglés | MEDLINE | ID: mdl-27110680

5.

MERAV: a tool for comparing gene expression across human tissues and cell types.

Shaul, Yoav D; Yuan, Bingbing; Thiru, Prathapan; Nutter-Upham, Andy; McCallum, Scott; Lanzkron, Carolyn; Bell, George W; Sabatini, David M.

Nucleic Acids Res; 44(D1): D560-6, 2016 Jan 04.

Artículo en Inglés | MEDLINE | ID: mdl-26626150

6.

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling.

Patterson, Heide Christine; Gerbeth, Carolin; Thiru, Prathapan; Vögtle, Nora F; Knoll, Marko; Shahsafaei, Aliakbar; Samocha, Kaitlin E; Huang, Cher X; Harden, Mark Michael; Song, Rui; Chen, Cynthia; Kao, Jennifer; Shi, Jiahai; Salmon, Wendy; Shaul, Yoav D; Stokes, Matthew P; Silva, Jeffrey C; Bell, George W; MacArthur, Daniel G; Ruland, Jürgen; Meisinger, Chris; Lodish, Harvey F.

Proc Natl Acad Sci U S A; 112(42): E5679-88, 2015 Oct 20.

Artículo en Inglés | MEDLINE | ID: mdl-26438848

7.

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.

Possemato, Richard; Marks, Kevin M; Shaul, Yoav D; Pacold, Michael E; Kim, Dohoon; Birsoy, Kivanç; Sethumadhavan, Shalini; Woo, Hin-Koon; Jang, Hyun G; Jha, Abhishek K; Chen, Walter W; Barrett, Francesca G; Stransky, Nicolas; Tsun, Zhi-Yang; Cowley, Glenn S; Barretina, Jordi; Kalaany, Nada Y; Hsu, Peggy P; Ottina, Kathleen; Chan, Albert M; Yuan, Bingbing; Garraway, Levi A; Root, David E; Mino-Kenudson, Mari; Brachtel, Elena F; Driggers, Edward M; Sabatini, David M.

Nature; 476(7360): 346-50, 2011 Aug 18.

Artículo en Inglés | MEDLINE | ID: mdl-21760589

8.

Critical role for IL-1ß in DNA damage-induced mucositis.

Kanarek, Naama; Grivennikov, Sergei I; Leshets, Michael; Lasry, Audrey; Alkalay, Irit; Horwitz, Elad; Shaul, Yoav D; Stachler, Matthew; Voronov, Elena; Apte, Ron N; Pagano, Michele; Pikarsky, Eli; Karin, Michael; Ghosh, Sankar; Ben-Neriah, Yinon.

Proc Natl Acad Sci U S A; 111(6): E702-11, 2014 Feb 11.

Artículo en Inglés | MEDLINE | ID: mdl-24469832

9.

Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade.

Shaul, Yoav D; Gibor, Gilad; Plotnikov, Alexander; Seger, Rony.

Genes Dev; 23(15): 1779-90, 2009 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-19651986

10.

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.

Lindquist, Robert A; Ottina, Kathleen A; Wheeler, Douglas B; Hsu, Peggy P; Thoreen, Carson C; Guertin, David A; Ali, Siraj M; Sengupta, Shomit; Shaul, Yoav D; Lamprecht, Michael R; Madden, Katherine L; Papallo, Adam R; Jones, Thouis R; Sabatini, David M; Carpenter, Anne E.

Genome Res; 21(3): 433-46, 2011 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-21239477

11.

Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold, Michael E; Brimacombe, Kyle R; Chan, Sze Ham; Rohde, Jason M; Lewis, Caroline A; Swier, Lotteke J Y M; Possemato, Richard; Chen, Walter W; Sullivan, Lucas B; Fiske, Brian P; Cho, Steve; Freinkman, Elizaveta; Birsoy, Kivanç; Abu, Monther-Remaileh; Shaul, Yoav D; Liu, Chieh Min; Zhou, Minerva; Koh, Min Jung; Chung, Haeyoon; Davidson, Shawn M; Luengo, Alba; Wang, Amy Q; Xu, Xin; Yasgar, Adam; Liu, Li; Rai, Ganesha; Westover, Kenneth D; Heiden, Matthew G Vander; Shen, Min; Gray, Nathanael S; Boxer, Matthew B; Sabatini, David M.

Nat Chem Biol; 12(8): 656, 2016 07 19.

Artículo en Inglés | MEDLINE | ID: mdl-27434767

12.

GENI: A web server to identify gene set enrichments in tumor samples.

Hayashi, Arata; Ruppo, Shmuel; Heilbrun, Elisheva E; Mazzoni, Chiara; Adar, Sheera; Yassour, Moran; Rmaileh, Areej Abu; Shaul, Yoav D.

Comput Struct Biotechnol J; 21: 5531-5537, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-38034403

13.

Depletion of Fumarate Hydratase, an Essential TCA Cycle Enzyme, Drives Proliferation in a Two-Step Model.

Solaimuthu, Balakrishnan; Lichtenstein, Michal; Hayashi, Arata; Khatib, Anees; Plaschkes, Inbar; Nevo, Yuval; Tanna, Mayur; Pines, Ophry; Shaul, Yoav D.

Cancers (Basel); 14(22)2022 Nov 09.

Artículo en Inglés | MEDLINE | ID: mdl-36428601

14.

DPYSL2 interacts with JAK1 to mediate breast cancer cell migration.

Abu Rmaileh, Areej; Solaimuthu, Balakrishnan; Khatib, Anees; Lavi, Shirel; Tanna, Mayur; Hayashi, Arata; Ben Yosef, Michal; Lichtenstein, Michal; Pillar, Nir; Shaul, Yoav D.

J Cell Biol; 221(7)2022 07 04.

Artículo en Inglés | MEDLINE | ID: mdl-35575798

15.

ERK1c regulates Golgi fragmentation during mitosis.

Shaul, Yoav D; Seger, Rony.

J Cell Biol; 172(6): 885-97, 2006 Mar 13.

Artículo en Inglés | MEDLINE | ID: mdl-16533948

16.

Monitoring Breast Cancer Growth and Metastatic Colony Formation in Mice using Bioluminescence.

Solaimuthu, Balakrishnan; Hayashi, Arata; Khatib, Anees; Shaul, Yoav D.

J Vis Exp; (177)2021 11 05.

Artículo en Inglés | MEDLINE | ID: mdl-34806708

17.

Large-Scale Differential Gene Expression Transcriptomic Analysis Identifies a Metabolic Signature Shared by All Cancer Cells.

Rmaileh, Areej Abu; Solaimuthu, Balakrishnan; Tanna, Mayur; Khatib, Anees; Yosef, Michal Ben; Hayashi, Arata; Lichtenstein, Michal; Shaul, Yoav D.

Biomolecules; 10(5)2020 04 30.

Artículo en Inglés | MEDLINE | ID: mdl-32365991

18.

2-APB and CBD-Mediated Targeting of Charged Cytotoxic Compounds Into Tumor Cells Suggests the Involvement of TRPV2 Channels.

Neumann-Raizel, Hagit; Shilo, Asaf; Lev, Shaya; Mogilevsky, Maxim; Katz, Ben; Shneor, David; Shaul, Yoav D; Leffler, Andreas; Gabizon, Alberto; Karni, Rotem; Honigman, Alik; Binshtok, Alexander M.

Front Pharmacol; 10: 1198, 2019.

Artículo en Inglés | MEDLINE | ID: mdl-31680972

19.

The MEK/ERK cascade: from signaling specificity to diverse functions.

Shaul, Yoav D; Seger, Rony.

Biochim Biophys Acta; 1773(8): 1213-26, 2007 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-17112607

20.

Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity.

Gershkovitz, Maya; Fainsod-Levi, Tanya; Khawaled, Saleh; Shaul, Merav E; Sionov, Ronit V; Cohen-Daniel, Leonor; Aqeilan, Rami I; Shaul, Yoav D; Fridlender, Zvi G; Granot, Zvi.

Cancer Res; 78(17): 5050-5059, 2018 09 01.

Artículo en Inglés | MEDLINE | ID: mdl-29967257

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